Nutraceuticals are widely appreciated for their beneficial effects in the human body providing support to the structure and functioning
Stinging nettle or common nettle, Urtica dioica, is a herbaceous perennial flowering plant, native to Europe, Asia, northern Africa, and North America, and is the best-known member of the nettle genus Urtica. The plant has many hollow stinging hairs called trichomes on its leaves and stems, which act like hypodermic needles, injecting histamine and other chemicals that produce a stinging sensation when contacted by humans and other animals. The plant has a long history of use as a medicine and as a food source needles, injecting histamine and other chemicals that produce a stinging sensation when contacted by humans and other animals. The plant has a long history of use as a medicine and as a food source. Stinging nettle is a dioecious herbaceous perennial, 1 to 2 m (3 to 7 ft) tall in the summer and dying down to the ground in winter. It has widely spreading rhizomes and stolons, which are bright yellow as are the roots. The soft green leaves are 3 to 15 cm (1 to 6 in) long and are borne oppositely on an erect wiry green stem. The leaves have a strongly serrated margin, a cordate base and an acuminate tip with a terminal leaf tooth longer than adjacent laterals. It bears small greenish or brownish numerous flowers in dense axillary inflorescences.
Hyperlipidemia is characterized by an elevation of total cholesterol, triglycerides, very-low-density lipoprotein cholesterol (VLDL-c), low-density lipoprotein cholesterol (LDL-c), free fatty acids, as well as reduced high-density lipoprotein cholesterol (HDL-c) levels. Among these the most common are hypercholesterolemia and hypertriglyceridemia which are the reason to cause ischemic heart disease3. It is estimated that raised cholesterol causes 2.6 million deaths worldwide. In 2008 the global prevalence of raised total cholesterol among adults (≥ 5.0 mmol/l) was 39% (37% for males and 40% for females). The World Health Organization has reported that Ischaemic heart disease was the leading cause of death, killing 111.4 thousand people in 2012 in Pakistan4.
Cholesterol is no doubt an important component required for a number of functions in human body but on the other hand excess amount of cholesterol above a limit is disastrous to the body.
Urtica Dioica is a common herb in most regions of the world. It is used to treat rheumatic pain, urinary tract infection and bladder stone. It has several pharmacological properties such as anti-inflammatory, antimicrobial, anti-oxidative activities hepato-protective and cardio protectives effects. The current study will examine the hypocholesterolemic effect of Urtica Dioica among the three different concentrations.